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在月经周期与整个妊娠期,子宫组织(生肌层、结缔组织、内膜上皮)进行生理与生化变化。在这方面,前列腺素(PG)起了重要作用。在分娩过程中,PG也积极参与,PG制剂不但能引起流产与发动分娩,而且PG合成抑制剂阿斯匹林与消炎痛能延迟中期引产的进行。但是,在正常分娩中,PG是否具有直接的发动分娩作用,就是说,在分娩发动前,PG的合成与释放是否已增加,或这时子宫对PG的反应是否变得更强烈,则尚未能明确证实。另外高效而作用短的PG中间产物(内过氧化合物)、凝血氧环(thromboxanes)与前列腺环素(prostacyclin)对子宫活化的作用也有待确定。
In the menstrual cycle and the entire pregnancy, uterine tissue (myometrial, connective tissue, endometrial epithelial) for physiological and biochemical changes. In this regard, prostaglandins (PG) play an important role. During labor, PG is also actively involved. PG preparations not only cause abortion and onset of labor, but also PG synthesis inhibitors aspirin and indomethacin can delay the induction of labor during the second trimester. However, does PG play a direct role in initiating labor in normal labor, that is, whether the synthesis and release of PG has increased before labor onset, or when the uterine response to PG becomes stronger at this time? Can be clearly confirmed. In addition, the role of efficient and short-acting PG intermediates (endoperoxides), thromboxanes and prostacyclin on uterine activation has yet to be determined.