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作者在1983～1986年,对343名健康成人接种了重组乙型肝炎疫苗.受试者的乙型肝炎标志均为阴性.将受试者分成5组,分别接种5批疫苗.免疫方法是分别于0、1和6个月在上臂三角肌接种3剂疫苗,每剂含10μg HBsAg.每次接种后连续5天记录体温和副作用情况,并在头7个月内每月以及9和12个月、然后是每年采血.加强接种疫苗大多与初次接种疫苗相同,并于加强接种后4周采血.用放射免疫法检测HBsAg、抗-HBs和抗-HBc.
The authors vaccinated 343 healthy adults with recombinant hepatitis B vaccine from 1983 to 1986. All subjects were negative for hepatitis B. The subjects were divided into 5 groups and each was vaccinated with 5 batches of vaccine, Three doses of the vaccine were administered to the deltoid muscle at 0, 1, and 6 months with 10 μg of HBsAg per dose. Body temperature and side effects were recorded for 5 consecutive days after inoculation and monthly for the first 7 months and 9 and 12 Months, followed by annual blood draws. Most of the booster vaccinations were the same as for the first vaccination, and blood was collected 4 weeks after boosting. HBsAg, anti-HBs and anti-HBc were detected by radioimmunoassay.