对苏云金杆菌内外毒素混合杀虫剂的毒性进行了较系统的研究。结果表明：该杀虫剂的经口、经皮急性毒性低，其ＬＤ（５０）均大于５０００ｍｇ／ｋｇ，无明显皮肤致敏、致突变、致畸、蓄积性和生殖毒性。有轻度的皮肤刺激作用，剂量达到１０ｍｇ／ｋｇ时呈现出免疫毒性作用。建议在农药的毒理学安全性评价程序中，增设免疫毒性的评价方法。 Toxicity of Bacillus thuringiensis toxin and mixed insecticides was systematically studied. The results showed that the insecticide had low oral and percutaneous acute toxicity and LD (50) of more than 5000 mg / kg. There was no obvious skin sensitization, mutagenicity, teratogenicity, accumulation and reproductive toxicity. A slight skin irritation, the dose reached 10mg / kg when showing immunotoxic effects. It is suggested that an evaluation method of immunotoxicity be added to the toxicological safety evaluation procedure of pesticides.