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目的研究肝肠钙粘连蛋白(LI-cadherin)在原发性肝癌组织中的表达及临床病理学的相关性.方法应用免疫组化ABC法分别检测35例肝癌组织、31例相应癌旁组织和10例正常肝脏组织中LI-cadherin的表达情况,并分析其临床病理学特征的相关性.结果 LI-cadherin在正常肝组织中不表达,在肝癌组织中的阳性表达率[68.6%(24/35)]明显高于癌旁组织[22.6%(7/31)]和正常组织(0/10)(P<0.05);LI-cadherin在肝癌组织中的表达与与肿瘤直径、门静脉癌栓及淋巴结转移呈负相关(P0.05).结论 LI-cadherin在原发性肝癌中高表达,其表达与肿瘤的直径、门静脉癌栓及淋巴结转移呈负相关,提示其在原发性肝癌的发生、发展起一定作用.“,”Objective: To study the expression of LI-cadherin in primary hepatocarcinoma(PHC)tissue and study of Clinicopathological. Methods: This investigation ABC wil detected the expression of LI-cadherin in 35 liver cancer specimens、31 liver corresponding paracarc inomas and 10 normal liver tissue slices by immunohistochemical staining and And then correlation among the clinical and pathological analysis . Results: LI-cadherin protein was not expressed in normal tissues, Positive expression rate in PHC significantly higher than normal tissue and adjacent ionnoncancerous tissues(P<0.05);LI-cadherin expression in hepatocelular carcinoma it has negtive correlation to the tumor size , tumor thrombus in portal-vein and lymph node metastasis,(P0.05). Conclusion: The high expression of LI - cadherin in primary liver cancer , is correlation to occurrence and development of primary hepatocarcinoma;LI-cadherin expression in primary hepatocarcinoma has negative correlation to the diameter of hepatocelular carcinoma, portal vein tumor thrombus and lymph node metastasis.