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对66名抗-HBc阳性者(其中儿童28名,成人38名)经3针乙肝疫苗免疫后,表现出3种不同类型的反应:原发免疫反应、继发免疫反应和无反应。血清抗-HBs阳转者的抗-HBs阳转率和浓度均明显低于对照组。抗-HBc的真正临床意义有待重新估价。
Sixty-six anti-HBc positive subjects (28 children and 38 adults) showed three different types of responses after three doses of hepatitis B vaccine: primary immune response, secondary immune response and no response. The anti-HBs positive rate and concentration of anti-HBs seroconversion in serum were significantly lower than those in control group. The true clinical significance of anti-HBc remains to be re-evaluated.