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为了更主动有效地防止葡萄胎恶变,国内外学者对葡萄胎的预防性化疗问题均极重视,并进行了一系列临床研究工作。预防性化疗的观点首先由Hreshchyshyn(1962)运用于妇科癌瘤病人。他根据在手术后实验动物血管中可获得肿瘤细胞,提出用化疗方法消除术时遗留或播散到血循环中的肿瘤细胞,以预防隐匿的“镜下病灶”发展。但未在临床运用。1966年Lewis第一个报道对葡萄胎病人用预防性化疗,并在其合理性上进行了探讨。认为正常的或肿瘤的滋养叶细胞具有侵犯血管和随血流远处转移的特性,
In order to prevent the hydatidiform mole more actively and effectively, both domestic and foreign scholars attach great importance to the preventive chemotherapy of hydatidiform mole and carry out a series of clinical research work. The concept of prophylactic chemotherapy was first used by Hreshchyshyn (1962) in gynecological cancer patients. Based on the availability of tumor cells in the blood of experimental animals after surgery, he proposed the use of chemotherapy to eliminate tumor cells left behind or disseminated into the bloodstream during surgery to prevent the development of occult “microscopic lesions.” But not in clinical use. Lewis first reported in 1966 to patients with hydatidiform mole preventive chemotherapy, and in its rationality were discussed. Trophoblast cells that are considered normal or of tumor have the properties of invading blood vessels and distant metastasis with blood flow,