论文部分内容阅读
糖尿病人及其治疗时常发生细胞内水转移与水排泄的生理学改变。近年研究证实糖尿病高血糖期血循环中精氨酸抗利尿素(A-VP)水平升高。由于糖尿病人血浆AVP水平升高并不减少水的排泄,因此糖尿病AV-P水平升高的临床意义及其重要性尚待进一步的研究解释。众所周知,口服磺酰脲类药,特别是氯磺丙脲,甲磺丁脲(甲糖宁)时有减低肾脏水廓清作用(CH_2O),而氯磺丙脲减低CH_2O的作用在临床具有重要意义。糖尿病人合并使用利尿剂治疗时可能增加氯磺丙脲的低纳血症,而高血糖本身的渗透性利
Diabetic patients and their treatment often occur within the physiological changes in water transfer and water excretion. In recent years, studies have confirmed that elevated blood levels of arginine and antiliurenin (A-VP) in diabetic hyperglycemic phase. Due to the elevated plasma AVP levels in diabetic patients does not reduce the excretion of water, the clinical significance and the importance of elevated AV-P levels in diabetic patients remains to be further elucidated. It is known that orally administered sulfonylureas, especially chlorpropamide and metribuzin, have the effect of reducing the water clearance of the kidneys (CH 2 O), while the reduction of CH 2 O by chlorpropamide is of clinical significance . Diabetes combined with diuretics may increase hypocalcemia chlorpromazine, while the permeability of hyperglycemia itself