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维生素K_3在临床上主要和为凝血药使用。近年来国内有些文献报道维生素K_3制剂也可作为平滑肌解痉药,并曾试用于治疗原发性痛经。因此,本文以大鼠离体子宫条实验对该药的作用机理进行了初步探讨。本试验选阴道涂片出现角化细胞(动情期)的体重为240～300g雌性大鼠作为实验对象,取其1.5cm长的子宫悬于容量为40ml的台氏液浴槽内,恒温37℃,并通以氧气,联以本教研室电子室自制的张力换能器,以自动记录仪记录收缩幅度,待自发收缩趋于稳定,开
Vitamin K_3 is mainly used clinically and for clotting drugs. In recent years, some domestic reports of vitamin K_3 preparations can also be used as smooth muscle spasm medicine, and has been tried in the treatment of primary dysmenorrhea. Therefore, this article in vitro rat uterus experiments on the mechanism of action of the drug for a preliminary study. The test selected vaginal smear keratinocytes (estrus) weight of 240 ~ 300g female rats as the experimental object, take its 1.5cm long uterus suspended in a capacity of 40ml of Tyrode’s Bath, constant temperature 37 ℃, And through the oxygen, combined with the room made by the Department of Zhang tension transducer to record the contraction rate of automatic recorder until the spontaneous contraction tends to be stable, open