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目的 检测CD44V8-10在胃癌中的表达,探讨其与胃癌临床病理特征之间的关系及意义.方法 用SP免疫组化方法检测CD44V8-10在63例胃癌中的表达,比较不同分化程度、是否转移、浸润深度及肿瘤部位阳性表达率的不同,探讨其间的关系.结果63例胃癌CD44V8-10阳性表达率为49.2%,高低分化腺癌阳性表达率分别为68.0%和36.8%(P<0.05),有无淋巴结转移的阳性表达率分别为54.4%和25.0%(P<0.05),有无远处转移的阳性表达率分别为76.9%和42.0O(P<0.05),浸润超过浆膜和未超过浆膜阳性表达率分别为55.0%和46.8%(P>0.05),贲门部癌和胃体、胃窦部癌阳性表达率分别为66.7%和45.1%(P>0.05).结论CD44V8-10阳性表达与胃癌分化程度、淋巴结转移及远处转移有关,与胃癌部位.浸润程度无关,并可能对高危预后病人的判断有一定价值.
Objective To detect the expression of CD44V8-10 in gastric cancer and explore its relationship with clinicopathological features of gastric cancer. Methods Immunohistochemistry was used to detect the expression of CD44V8-10 in 63 cases of gastric cancer. The differences in metastasis, depth of invasion, and positive expression rate of tumor sites were explored. The results showed that the positive rate of CD44V8-10 was 49.2% in gastric cancer, and 68.0% and 36.8% in high and low differentiated adenocarcinoma, respectively (P<0.05). The positive rate of lymph node metastasis was 54.4% and 25.0% (P<0.05), and the positive rate of distant metastasis was 76.9% and 42.0O (P<0.05), infiltration over the serosa and The positive expression rates of the serosa did not exceed 55.0% and 46.8%, respectively (P>0.05). The positive rates of cancer of the cardia, gastric body and gastric antrum were 66.7% and 45.1%, respectively (P>0.05). Conclusion CD44V8- 10 The positive expression was related to the degree of differentiation of gastric cancer, lymph node metastasis and distant metastasis. It was not related to the degree of invasion of gastric cancer. It may have some value in the judgment of high-risk prognosis.