The Xiangshan uranium deposit in Jiangxi province is one of the most important uranium deposits in China. The aim of our study is to obtain a better understanding of rock deformation and dilation associated with mineralization, to predict the most favorable locations of mineralization, and to assist with future mineral exploration in this deposit. On the basis of geological and structural data from previous studies, we have constructed a coupled deformation and fluid flow numerical model and simulated the faulting deformation and major mechanical factors controlling mineralization in the deposit. Particular attention has been paid to variations in regional stress, distributions of shear strain, volumetric strain and pore pressure. The relationship between the struc-tural/faulting movement and mineralization is obtained through analyzing the deformation state of fault zones. The results suggest that the mineralization is related to volumetric strain, shear strain and pore pressures. The locations displaying all these factors rep-resent the most favorable sites for mineralization. These model results are important for guiding the exploration of new uranium deposits in Xiangshan. The aim of our study is to obtain a better understanding of rock deformation and dilation associated with mineralization, to predict the most favorable locations of mineralization, and to assist with the future of mineral exploration in this deposit. On the basis of geological and structural data from previous studies, we have constructed a coupled deformation and fluid flow numerical model and simulated the faulting deformation and major mechanical factors controlling mineralization in the deposit. paid to variations in regional stress, distributions of shear strain, volumetric strain and pore pressure. The relationship between the struc-tural / faulting movement and mineralization is obtained through analyzing the deformation state of fault zones. The results suggest that the mineralization is related to volumetric strain, shear strain and pore pressures locations displaying all these factors rep-resent the most favorable sites for mineralization. These model results are important for guiding the exploration of new uranium deposits in Xiangshan.