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目的:探讨儿童急性淋巴细胞白血病分型对预后的影响,为临床治疗提供依据。方法:回顾性分析2007年1月~2008年12月我院收治的急性淋巴细胞白血病患儿32例,比较不同分型的预后情况。结果:ALL-L1、ALL-L2与ALL-L3的首次诱导CR率(X2=1.087,P>0.05)、完全CR率(X2=0.607,P>0.05),差异无统计学意义;CR的治疗时间(t=6.001,P<0.05)、3年生存率(X2=9.458,P<0.05),差异有统计学意义。T-ALL、B-ALL的首次诱导CR率(X2=8.891,P<0.05)、达到CR治疗时间(t=6.361,P<0.05)、完全CR率(X2=11.892,P<0.05),差异有统计学意义。两型的3年生存率(X2=1.536,P>0.05),差异有统计学意义。B-ALL中各型别首次诱导CR率(X2=0.494,P>0.05)和完全CR率(X2=0.405,P>0.05),差异统计学意义。B-ALL中各型别达到CR的治疗时间(t=7.007,P<0.05)和3年生存率(X2=6.609,P<0.05),差异有统计学意义。结论:儿童急性白血病其预后与其分型有一定的相关性,因此临床治疗应结合患儿的分型进行个体化治疗。
Objective: To investigate the prognosis of children with acute lymphoblastic leukemia and provide the basis for clinical treatment. Methods: A retrospective analysis of 32 cases of acute lymphoblastic leukemia admitted to our hospital from January 2007 to December 2008, the prognosis of different types were compared. Results: The first-time CR rate (X2 = 1.087, P> 0.05) and the complete CR rate (X2 = 0.607, P> 0.05) were not significantly different between ALL-L1, ALL-L2 and ALL- Time (t = 6.001, P <0.05), 3-year survival rate (X2 = 9.458, P <0.05), the difference was statistically significant. The CR rate (X2 = 8.891, P <0.05) and the CR rate (t = 6.361, P <0.05) There is statistical significance. Three-year survival rate of two types (X2 = 1.536, P> 0.05), the difference was statistically significant. The CR rate (X2 = 0.494, P> 0.05) and complete CR rate (X2 = 0.405, P> 0.05) were the highest in all the types of B-ALL, the difference was statistically significant. The treatment time (t = 7.007, P <0.05) and 3-year survival rate (X2 = 6.609, P <0.05) of each type of B-ALL reached CR, the difference was statistically significant. Conclusion: The prognosis of children with acute leukemia has a certain correlation with its classification. Therefore, clinical treatment should be combined with the classification of children for individualized treatment.