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慢性阻塞性肺疾病时肺动脉高压的程度是决定病人寿命的重要因素。肺动脉高压的发病机理主要是小的肺动脉和肺泡血管缺氧性收缩。最初,借血管收缩可维持正常的通气-灌注比例,但由于肺泡长期缺氧,肺血管持久狭窄,导致毛细血管阻力增大,肺动脉压明显升高;慢性缺氧尚可引起肺血管的器质性病变。肺血管收缩的主要机理是钙进入细胞内,如抑制钙的转运则可使缺氧性肺血管收缩减轻,故可以作为钙离子拮抗剂治疗缺氧性肺动脉高压的依据。作者观察慢性非特异性肺病13(男11,女2)例
The extent of pulmonary hypertension in chronic obstructive pulmonary disease is an important factor in determining the patient’s lifespan. The pathogenesis of pulmonary hypertension is mainly the small pulmonary artery and pulmonary vascular hypoxia contraction. Initially, by the vasoconstriction can maintain the normal ventilation - perfusion ratio, but due to chronic alveolar hypoxia, pulmonary vascular stenosis, leading to increased capillary resistance, pulmonary hypertension was significantly increased; chronic hypoxia can cause pulmonary vascular quality Sexually transmitted diseases. Pulmonary vasoconstriction is the main mechanism of calcium into the cells, such as inhibition of calcium transport can reduce hypoxic pulmonary vasoconstriction, it can be used as a calcium ion antagonist hypoxia-induced pulmonary hypertension based. The authors observed chronic nonspecific lung disease 13 (male 11, female 2) cases