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目的:探讨丹参对急性脊髓损伤的影响及作用机制。方法:36只SD大鼠随机分为正常对照组、模型对照组和丹参治疗组。在建立脊髓损伤动物模型后,分别给模型对照组大鼠注射生理盐水、丹参治疗组大鼠注射复方丹参注射液,观测脊髓组织学及超微结构变化。结果:经复方丹参治疗14d后,大鼠脊髓前角运动神经体积密度(Vv)值为8.34±0.3,用药剂量为2g/(kg·d)时Vv值增大,脊髓内髓鞘断裂减轻,吞噬细胞清除组织降解物,神经元变性恢复。结论:丹参对大鼠急性脊髓损伤后神经修复及再生有促进作用。
Objective: To investigate the effects of salvia miltiorrhiza on acute spinal cord injury and its mechanism of action. Methods: Thirty-six SD rats were randomly divided into normal control group, model control group and Salvia miltiorrhiza treatment group. After establishing an animal model of spinal cord injury, rats in the model control group were injected with normal saline and Salvia miltiorrhiza treatment group to inject compound salvia miltiorrhiza injection, and the histological and ultrastructural changes of the spinal cord were observed. RESULTS: After 14 days of compound salvia miltiorrhiza, the Vv value of the motor nerve in the anterior horn of the spinal cord was 8.34±0.3. When the dose was 2g/(kg·d), the Vv value increased, and the myelin sheath ruptured in the spinal cord. Phagocytic cells remove tissue degradants and neurons degenerate. Conclusion: Salvia miltiorrhiza can promote nerve repair and regeneration after acute spinal cord injury in rats.