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为了探讨人乳头瘤病毒（ＨＰＶ）与宫颈癌之间的相关性，我们收集了全国宫颈癌高发县之一的略阳县１２例宫颈癌，１２例宫颈间变，３６例宫颈Ⅱ～Ⅲ度糜烂患者的组织标本，经抽提ＤＮＡ以后，以［ａ－３２Ｐ］ｄＡＴＰ标记ＨＰＶ１６、１８型ＤＮＡ进行打点杂交。结果为宫颈癌ＨＰＶ１６阳性６例，ＨＰＶ１８阳性１例。宫颈间变ＨＰＶ１６阳性４例，ＨＰＶ１８阳性１例。ＨＰＶ１６阳性率分别为５０％和３３．３％，ＨＰＶ１８阳性率为８．３％。宫颈糜烂Ⅱ～Ⅲ度的患者组织ＤＮＡ与ＨＰＶ１６、ＨＰＶ１８混合杂交阳性１７例，阳性率为４７．２％。
To investigate the correlation between human papillomavirus (HPV) and cervical cancer, we collected 12 cases of cervical cancer in Lueyang County, one of the high incidence of cervical cancer in our country, 12 cases of cervical varicosity, 36 cases of cervical Ⅱ ~ Ⅲ degree Erosion patients with tissue samples, after the extraction of DNA, to [a-32P] dATP HPV16,18 type DNA dotted hybridization. The results of cervical cancer HPV16-positive in 6 cases, HPV18-positive in 1 case. Cervical varicocele HPV16-positive in 4 cases, HPV18-positive in 1 case. The positive rate of HPV16 was 50% and 33.3% respectively, and the positive rate of HPV18 was 8.3%. Cervical erosion in patients with Ⅱ ~ Ⅲ degree of DNA and HPV16, HPV18 hybrid positive 17 cases, the positive rate was 47.2%.