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对慢性阻塞性肺病(COPD)与肺心病12例患者及无肺胸疾患的5名志愿者进行氨茶碱负荷剂量(6mg/kg)快速静滴,以放射性核素~(113)In观察其用药前后的LVEF,LVER及FEV_(1.0)、FVC、动脉血气分析。同时测血清氨茶碱浓度。GOPD,肺心病12例,临床上无冠心病诊断依据,但10/12例(85％)显示LVEF异常,且下降程度与病情一致,提示该类患者左心受累。结果表明:(1)静滴氨茶碱后可以改善该类患者的左心功能及通气功能。(2)静滴氨茶碱负荷剂量可以使血清茶碱浓度达治疗中水平。认为氨茶碱可以成为该类患者缓解期治疗的方法。
Twelve patients with chronic obstructive pulmonary disease (COPD) and pulmonary heart disease and five volunteers without pulmonary thoracic disease were given intravenous infusion of aminophylline (6 mg / kg) rapidly and intravenously to observe the effect of radionuclide (113) In Before and after treatment of LVEF, LVER and FEV_ (1.0), FVC, arterial blood gas analysis. Simultaneous serum aminophylline concentrations. GOPD, pulmonary heart disease in 12 cases, no clinical diagnosis of coronary heart disease, but 10/12 cases (85%) showed abnormal LVEF, and the degree of decline consistent with the disease, suggesting that patients with left heart involvement. The results showed that: (1) intravenous aminophylline can improve left ventricular function and ventilatory function in these patients. (2) intravenous infusion of aminophylline dose serum serophyll concentration reached the level of treatment. Aminophylline that can be such patients remission treatment methods.