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目的：探讨肺癌ＭＲＩ信号及形态特征与ＤＮＡ倍体的关系。材料和方法：２６例原发性支气管肺癌患者，术前用Ｒｅｓｏｎｅｘ ０．３８Ｔ磁共振成像仪行冠状面及横断面成像（ＳＥ Ｔ１ＷＩ和ＧＲ），增强后行横断面ＳＥ Ｔ１ＷＩ。术后肺癌标本用细胞图像分析仪，测定每例患者的ＤＮＡ含量及Ｓ期分数（ＳＰＦ）。结果：未增强Ｔ１ＷＩ异倍体肿瘤信号强度比显著大于二倍体肿瘤的信号强度比。异倍体肿瘤的ＳＰＦ值也显著大于二倍体肿瘤，ＭＲＩ形态特征（大小、分叶、毛刺、坏死）不能反映ＤＮＡ指数和ＳＰＦ。结论：ＭＲＩ信号强度比在一定程度上可反映肿瘤细胞的ＤＮＡ含量，信号强度高的肺癌细胞较信号强度低者ＤＮＡ含量高。
Objective: To investigate the relationship between MRI signal and morphological features of lung cancer and DNA ploidy. MATERIALS AND METHODS: Twenty-six patients with primary bronchogenic carcinoma were enrolled. Coronal and transverse sections (SE T1WI and GR) were preoperatively reconstructed with the Resonex 0.38T magnetic resonance imager to enhance the posterior cross-sectional SE T1WI. Postoperative lung cancer specimens with a cell image analyzer to determine the DNA content of each patient and S-phase fraction (SPF). Results: The signal intensity ratio of non-enhanced aneuploid tumors was significantly greater than that of diploid tumors. The SPF of aneuploid tumors was also significantly larger than that of diploid tumors. The morphological features of MRI (size, lobulation, burr, necrosis) did not reflect DNA index and SPF. Conclusion: MRI signal intensity ratio can reflect the DNA content of tumor cells to a certain extent. The lung cancer cells with higher signal intensity have higher DNA content than those with lower signal intensity.