以氯噻啉为先导,利用类同合成方法,保留氯噻啉结构中噻唑环2-位氯原子,通过变换噻唑环4-位取代基,设计合成了8个氯噻啉类似物。所有化合物的结构均经~1H NMR、~(13)C NMR、质谱及元素分析等确认。初步生物活性测试结果表明:该类化合物具有一定的杀虫活性。在200μg/m L的浓度下,化合物8a和8g对桃蚜(Myzus persicae)致死率达70%。 Using chlorothiazine as the precursor, 8 chlorine atoms of the thiazole ring in the chlorothiazine structure were retained by similar synthetic methods. Eight chlorothiazine analogues were designed and synthesized by changing the 4-position substituent of the thiazole ring. The structures of all the compounds were confirmed by ~ 1H NMR, ~ (13) C NMR, MS and elemental analysis. Preliminary biological activity test results show that: these compounds have certain insecticidal activity. At the concentration of 200μg / m L, the lethality of compounds 8a and 8g to Myzus persicae was 70%.