论文部分内容阅读
目的:研究吗啡及胆碱能系统的药物对大鼠空间学习能力的影响 方法:应用Morris水迷宫学习程序研究吗啡处理大鼠的空间学习能力及其在东莨菪碱和毒扁豆碱作用下的变化.结果:高剂量吗啡(10mg/kg)和低剂量吗啡(3mg/kg)对大鼠学习能力的影响差异有显著性;东莨菪碱(3mg/kg)和吗啡(10mg/kg)联合给药,可以使吗啡时学习能力的损害进一步加重;毒扁豆碱(0.1mg/kg)可以改善吗啡所致的学习能力损害,但不能完全逆转.结论:吗啡损害大鼠空间学习能力,已存在量-效关系;胆碱能系统与吗啡处理大鼠空间学习能力关系密切,有可能影响成瘾的发生及治疗.
OBJECTIVE: To study the effects of morphine and cholinergic drugs on spatial learning ability in rats.Methods Morris water maze learning program was used to study the spatial learning ability of morphine-treated rats and their changes under scopolamine and physostigmine.Results (10mg / kg) and low dose morphine (3mg / kg) had significant difference on the learning ability of rats. Scopolamine (3mg / kg) and morphine (10mg / kg) (0.1mg / kg) could improve morphine-induced impairment of learning ability, but not completely reversed.Conclusion: There is a dose-effect relationship between morphine and spatial learning ability in rats Alkaline system and morphine treatment of spatial learning ability of rats is closely related, may affect the occurrence and treatment of addiction.