论文部分内容阅读
目的:探讨葡萄糖转运蛋白3(glucose trans porterproteins,GLUT3)在胶质瘤中的表达及其临床意义。方法:用免疫组化Envision法检测80例胶质瘤GLUT3的表达。结果:①在胶质瘤中,GLUT3在Ⅰ、Ⅱ、Ⅲ、Ⅳ级的阳性率分别为35%,60%,80%,100%,在对照组中无表达,各组间有显著差异(χ2=37.19,P<0.01);②各级胶质瘤,表达强度随胶质瘤病理级别增加而增加(r=0.6906,P<0.0001);③GLUT3表达分别与患者年龄(χ2=1.05,P>0.05)、性别(χ2=0.15,P>0.05)、肿瘤大小(χ2=0.30,P>0.05)、部位无关(χ2=0.74,P>0.05)。结论:GLUT3在胶质瘤中的表达强度分别与肿瘤的病理级别呈正相关,可以作为判断胶质瘤生物学行为、预测病人预后的重要指标。
Objective: To investigate the expression of glucose transporter 3 (GLUT3) in gliomas and its clinical significance. Methods: The immunohistochemical Envision method was used to detect the expression of GLUT3 in 80 gliomas. Results ① In gliomas, the positive rates of GLUT3 in grade Ⅰ, Ⅱ, Ⅲ and Ⅳ were 35%, 60%, 80% and 100%, respectively. There was no significant difference between the two groups χ2 = 37.19, P <0.01); ② The expression of glioma at all levels increased with the pathological grade of glioma (r = 0.6906, P <0.0001) (Χ2 = 0.15, P> 0.05), tumor size (χ2 = 0.30, P> 0.05), but not location (χ2 = 0.74, P> 0.05). CONCLUSION: The positive expression of GLUT3 in gliomas correlates with the pathological grade of glioma, which can be used as an important index to judge the biological behavior of glioma and predict the prognosis of glioma.