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目的 研究重组人生长激素对卵巢切除后已发生明显骨丢失大鼠松质骨的影响。方法 6月龄 SD雌性大鼠卵巢切除 3个月后开始接受低、中、高三种剂量重组人生长激素皮下注射 8周，采用骨密度测定、骨组织形态计量学等手段研究大鼠腰椎松质骨的改变。结果 重组人生长激素显著增加骨质疏松大鼠的骨密度，对改善松质骨骨量及骨结构参数都有显著作用。 1.0 mg· kg-1· d-1治疗组效果最佳。结论 重组人生长激素能够促进骨质疏松大鼠骨量恢复，并能够显著改善松质骨的结构，其作用效果与重组人生长激素的剂量有关。
Objective To study the effect of recombinant human growth hormone on the cancellous bone in rats with significant bone loss after ovariectomy. Methods Six-month-old SD female rats were ovariectomized for 3 months and then received low, medium and high doses of recombinant human growth hormone subcutaneously for 8 weeks. BMD and bone histomorphometry were used to study the lumbar spongy Bone changes. Results Recombinant human growth hormone significantly increased the bone mineral density in osteoporotic rats and played a significant role in improving cancellous bone mass and bone structure parameters. 1.0 mg · kg-1 · d-1 treatment group best. Conclusions Recombinant human growth hormone can promote the recovery of bone mass in osteoporotic rats and can significantly improve the structure of cancellous bone. The effect of recombinant human growth hormone is related to the dosage of recombinant human growth hormone.