大量致畸物可以引起哺乳动物的腭裂(cleftpalate).许多对致畸物所致的腭裂的研究主要局限于上腭组织分化的形态学和生物化学。传统的致畸试验费时耗资,且只能测试少数的化学物。因此,用短期体外测试方法来评价化学物的致畸作用已日益被重视。多年来,不少作者试图从腭裂形成的机理上建立一短期致畸物筛选方法,以提供须经活体致畸试验评判的优先考虑的化学物名单。 A large number of teratogens can cause mammalian cleft palate Many studies of teratogenic cleft palate have been mainly confined to morphology and biochemistry of palate tissue differentiation. Traditional teratogenic tests are time-consuming and can only test a few chemicals. Therefore, the short-term in vitro test methods to evaluate the teratogenic effects of chemicals have been increasingly valued. Over the years, many authors have attempted to establish a short-term teratogen screening method from the mechanism of cleft palate formation in order to provide a list of preferential chemicals to be assessed by in vivo teratogenicity tests.