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采用姐妹染色单体互换（ＳＣＥ）技术，对粤东地区２０例弥散性甲状腺肿伴功能亢进症（简称甲亢）自发的和丝裂霉素Ｃ诱发的ＳＣＥ频率进行了检测，并与２０例正常健康人作比较。结果表明甲亢患者平均白发和诱发的ＳＣＥ频率分别为１１．１００±０．１３９／细胞（０．２５１±０．００３／染色体）和２３．６００±０．１９８／细胞（０．５１０±０．００４／染色体），均高于正常健康人［分别为８．１００±０．１１６／细胞（０．１７６±０．００４／染色体）和１７．５００±０．１７３／细胞（０．３９２±０．００３／染色体）］。提示甲亢可能与ＤＮＡ的损伤修复缺陷有关系。甲亢患者诱发的姐妹染色单体频率的增加数（１２．４５０±１３．５２８）明显高于正常健康人（９．４００±０．０５７），提示前者体细胞染色体（ＤＮＡ）修复功能较后者低下。
Sister chromatid exchange (SCE) technique was used to detect spontaneous and mitomycin C-induced SCE frequency in 20 cases of diffuse goiter complicated with hyperthyroidism in eastern Guangdong and 20 cases Normal healthy people for comparison. The results showed that average white hair and induced SCE frequency in hyperthyroid patients were 11.100 ± 0.139 / cell (0.251 ± 0.003 / chromosome) and 23.600 ± 0.198 / cell (0.510 ± 0 .004 / chromosome) were higher than those in healthy subjects [8.100 ± 0.116 cells / (0.176 ± 0.004 / chromosome) and 17.500 ± 0.173 cells / (0.392 ± 0.003 / chromosome)]. Tip hyperthyroidism may be related to DNA damage repair defects. The increase of sister chromatid frequency (12.450 ± 13.528) in patients with hyperthyroidism was significantly higher than that of normal healthy people (9.400 ± 0.057), suggesting that the former had more chromosome DNA repair function than the latter low.