论文部分内容阅读
目的研究根除幽门螺杆菌(Hp)对儿童再发性腹痛(RAP)3年内转归的影响。方法将35例幽门螺杆菌粪便抗原检测(HpSA)阳性的RAP儿童给予抗Hp三联法治疗2周,随访3年,每年复查1次HpSA,如仍阳性,再给予抗Hp三联法治疗2周,观察Hp根除率对RAP复发的影响和每年RAP总复发率。结果 Hp根治失败或Hp再感染的每年腹痛复发率分别为81.8%、80.0%、75.0%。根治后Hp转阴者每年腹痛复发率是12.5%、12.0%、11.1%,两者比较差异有统计学意义(P<0.05);1~3年RAP总复发率分别为34.3%、31.4%、25.7%(P>0.05),差异无统计学意义。结论 Hp感染与RAP发生有关,根除幽门螺杆菌能显著降低RAP复发率,改善RAP患儿的预后;但继续抗Hp治疗不能显著再降低RAP复发率。
Objective To investigate the effect of Helicobacter pylori eradication (Hp) on the outcomes of recurrent abdominal pain (RAP) in children within 3 years. Methods 35 HpSA positive RAP children were given anti-Hp triple therapy for 2 weeks and were followed up for 3 years. HpSA was re-examined once a year. If HpSA was still positive, anti-Hp triple therapy was given for 2 weeks, To observe the impact of Hp eradication rate on the recurrence of RAP and the annual recurrence rate of RAP. Results The recurrence rates of abdominal pain were 81.8%, 80.0% and 75.0%, respectively. The recurrence rates of Hp-negative patients after cure were 12.5%, 12.0% and 11.1% respectively (P <0.05), and the recurrence rates of RAP in one to three years were 34.3% and 31.4% 25.7% (P> 0.05), the difference was not statistically significant. Conclusions Hp infection is related to the occurrence of RAP. Eradication of H. pylori can significantly reduce the recurrence rate of RAP and improve the prognosis of children with RAP. However, the continued anti-Hp treatment can not significantly reduce the recurrence rate of RAP.