论文部分内容阅读
新近发现的RASSF1A基因位于染色体3p21.3区,是一种新型侯选肿瘤抑制基因,多项研究表明它可参与细胞凋亡和多种恶性肿瘤的发生。在多种肿瘤中失活。该基因的失活与其启动子区甲基化和杂合子缺失有关。另外发现一些病毒的感染可影响其甲基化状态。
The newly discovered RASSF1A gene is a novel candidate tumor suppressor gene located on chromosome 3p21.3. Several studies have shown that it can participate in the apoptosis and the occurrence of many malignant tumors. In many tumors inactivation. Inactivation of this gene is related to its promoter methylation and loss of heterozygotes. In addition, some viruses have been found to affect their methylation status.