Charcot osteoarthropathy (COA) is a potentially limbthreatening condition that mainly affects diabetic patients with neuropathy. In everyday practice, it presents as a red, hot, swollen foot, usually painless, and is frequently trig gered by trivial injury. Its etiology is traditionally attributed to impairment of either the autonomic nervous system, leading to increased blood flow and bone resorption, or of the peripheral nervous system, whereby loss of pain and protective sensation render the foot susceptible to repeated injury. More recently, excessive local inflammation is thought to play a decisive role. Diagnosis is based on clinical manifestation and imaging studies (plain X-rays, bone scan, Magnetic Resonance Imaging). The mainstay of management is immediate off-loading, while surgery is usually reserved for chronic cases with irreversible deformities and/or joint instability. The aim of this review is to provide an overview of COA in terms of pathogenesis, classification and clinical presentation, diagnosis and treatment, with an emphasis on the high suspicion required by clinicians for timely recognition to avoid further complications. In everyday practice, it presents as a red, hot, swollen foot, usually painless, and is frequently trigged by ge trivial injury. Its etiology is traditionally attributed to impair of either the autonomic nervous system, leading to increased blood flow and bone resorption, or of the peripheral nervous system, characterized loss of pain and protective sensation render the foot susceptible to repeated injury. More recently, excessive local inflammation is thought to play The mainstay of management is immediate off-loading, while surgery is usually reserved for chronic cases with irreversible deformities and / or joint instability. The aim of this review is to provide an overview of COA in terms of pathogenesis, classification and c linical presentation, diagnosis and treatment, with an emphasis on the high suspicion required by clinicians for timely recognition to avoid further complications.