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最近报道,美国、日本95%以上的输血后肝炎是非甲非乙型肝炎。而输血后非甲非乙型肝炎的发病率达10～15%。虽然,多数急性的非甲非乙型肝炎临床是轻微的或无症状的,但有证据提示,感染者可以发展成慢性肝脏疾病。黑猩猩不仅对HAV和HBV是敏感的,而且以后发现对非甲非乙型肝炎病毒也敏感。本文接种用的动物是纯种黑猩猩,方法是用污染了非甲非乙型肝炎病毒的第Ⅷ因子材料30毫升,接种于二只黑猩猩(No771,No921),再取No 771黑猩猩感染后急性期肝脏制剂,经CsCl梯度离心后,取浮悬密度平均为
More recently, more than 95% of post-transhepatitic hepatitis in the United States and Japan is non-A, non-B hepatitis. The incidence of non-A non-B hepatitis after transfusion reached 10 to 15%. Although most acute non-A, non-B hepatitis are clinically mild or asymptomatic, there is evidence that people with HIV may develop chronic liver disease. Chimpanzees are not only sensitive to HAV and HBV, but are also found to be sensitive to non-A, non-B hepatitis viruses. The vaccinated animals were purebred chimpanzee. Thirty milliliters of factor VIII-contaminated non-A, non-B hepatitis virus was inoculated into two chimpanzees (No771, No921) and then an A771 chimpanzee acute phase Liver preparations, after CsCl gradient centrifugation, to take the average floating suspension density