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目的探讨孕妇血清生化标志物甲胎蛋白(AFP)、绒毛膜促性腺激素(βHCG)和游离雌三醇(uE3)对孕中期孕妇进行唐氏综合征为主的先天缺陷筛查的作用。方法对孕中期(14～20w)妇女进行上述三项血清生化指标检测,经过软件计算风险,对可能影响检测结果的部分因素,如孕妇年龄、体重、孕周等加以分析校正,对高风险孕妇,进一步行羊水或脐血染色体检查及B超进行确诊。结果 1965例孕妇中,发现唐氏综合征2例,神经管缺陷1例。结论孕中期血清AFP、βHCG和uE3三项血清生化指标联合检测,对于严重先天性缺陷儿的宫内诊断具有重要的临床价值,筛查结果高危孕妇应进一步行羊水染色体或B超检查确诊,以减少缺陷儿出生。
Objective To investigate the role of pregnant women’s serum biochemical markers of AFP, βHCG and uE3 in the screening of Down’s syndrome-based birth defects in pregnant women in the second trimester. Methods The above three serum biochemical indexes were measured in the second trimester (14 ~ 20w) women. The software was used to calculate the risk. Some factors that may affect the test result, such as the age, weight and gestational age of the pregnant women, were analyzed and corrected. , Further line of amniotic fluid or cord blood chromosomes and B ultrasound diagnosis. Results 1965 pregnant women, found in 2 cases of Down Syndrome, 1 case of neural tube defects. Conclusions The combined detection of three serum biochemical markers AFP, βHCG and uE3 in the second trimester of pregnancy has important clinical value for intrauterine diagnosis of children with severe congenital defects. High risk pregnant women with screening results should be diagnosed by amniotic fluid chromosome or B- Reduce defective children born.