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采用离子感胶化法制备亲水性壳聚糖纳米粒。该法制备条件温和 ,是在室温下将两种水相混合而形成纳米粒。混合的两相中 ,其中一相含有壳聚糖和聚氧乙烯 ,另一相含有聚阴离子三聚磷酸钠。该纳米粒的粒度大小及 ζ电位可以通过控制制剂处方组成及工艺进行调节。采用该法制备的胰岛素壳聚糖纳米粒 ,实验结果表明 ,胰岛素的包封率可高达 90 % ,且制剂处方及工艺各因素对该纳米粒的包封率有不同程度的影响。该亲水性纳米粒可作为蛋白质或其它能与壳聚糖相互作用的大分子类药物给药系统的载体。
Hydrophilic chitosan nanoparticles were prepared by iontophoresis. The preparation method of the method is mild, and the two kinds of water phases are mixed to form the nano-particles at room temperature. Of the two phases mixed, one of the phases contains chitosan and polyoxyethylene and the other phase contains the polyanionic sodium tripolyphosphate. The particle size and zeta potential of the nanoparticles can be controlled by controlling the formulation and process of the formulation. The insulin chitosan nanoparticles prepared by this method showed that the entrapment efficiency of insulin could be as high as 90%, and the preparation prescription and process factors had different effects on the entrapment efficiency of the nanoparticles. The hydrophilic nanoparticles can serve as a carrier for proteins or other macromolecular drug delivery systems that can interact with chitosan.