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目的 调查研究接煤尘工人尿N 乙酰 β D 氨基葡萄糖苷酸酶 (NAG)活性和血自由基变化。 方法 选择接煤尘为 0、5、10、15和 2 0年的工人为研究对象 ,取工人静脉血测定血浆肌酐 (Cr)、一氧化氮 (NO)、超氧化物歧化酶 (SOD)和丙二醛 (MDA) ,同时测定尿NAG酶活性 ,并进行比较分析。结果 接煤尘组血浆Cr均在正常范围内 ,但接煤尘 15年组和 2 0年组高于对照组 (P <0 0 1) ,血浆NO、SOD和MDA水平同对照组比较 ,差异有显著意义 (分别为P <0 0 5、P <0 0 1) ,接煤尘组尿NAG均高于对照组 ,10年组至 2 0年组有统计学意义 (P <0 0 1)。结论 工人接煤尘时间越长 ,肾损害越重 ,尿NAG越高 ,尿NAG测定有助于肾损害的早期诊断。
Objective To investigate the changes of urinary N acetyl beta D glucosaminidase (NAG) activity and blood free radical in workers exposed to coal dust. Methods The workers who took coal dust for 0, 5, 10, 15 and 20 years were selected as the study objects. The venous blood of workers was used to measure the levels of plasma creatinine (Cr), nitric oxide (NO), superoxide dismutase Malondialdehyde (MDA), urine NAG enzyme activity, and comparative analysis. Results Plasma Cr in the coal dust group was within the normal range, but the levels of NO, SOD and MDA in the 15-year group and 20-year group were higher than those in the control group (P <0.01) (P <0.01, P <0.01). The urinary NAG in the coal dust group was significantly higher than that in the control group, and the difference was statistically significant between the 10-year group and the 20-year group (P <0.01) . Conclusion The longer the worker takes the coal dust, the more severe the renal damage is, the higher the urinary NAG is and the urinary NAG determination is helpful for the early diagnosis of renal damage.