作者对19例神经母细胞瘤(NBL)的活检病例中13例作PAS、网状纤维染色及神经原特异性烯醇化酶(NSE)免疫组化研究,着重探讨NSE免疫组化染色定位对NBL在病理诊断,鉴别诊断及组织学分级中的意义。结果除2例阴性者排除NBL外,11例均呈阳性反应。另外4例NSE阳性者同时PAS染色阳性。17例NBL按组织学分为三级:一级为神经节神经母细胞瘤,又称分化好的NBL,2例;二级为低分化的NBL,8 Thirteen of 19 biopsies from neuroblastoma (NBL) were studied immunohistochemically with PAS, reticulo-fiber staining and neuron-specific enolase (NSE). We investigated the effect of NSE immunohistochemical staining on NBL Significance in pathological diagnosis, differential diagnosis and histological grade. Results In addition to two cases of negative NBL excluded, 11 cases were positive. Another 4 cases of positive NSE positive PAS staining. 17 cases of NBL according to histology is divided into three levels: one for the ganglioneuroblastoma, also known as well-differentiated NBL, 2 cases; two poorly differentiated NBL, 8