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目的:了解静脉吸毒人群丙氨酸氨基转氨酶(ALT)异常与丙型肝炎病毒(HCV)感染之间的关系,为控制丙型肝炎的传播提供科学依据。方法:用连续监测法检测ALT,同时用酶联免疫吸附法试验(ELISA)进行丙型肝炎病毒抗体(抗-HCV)的检测,并与同期检测的ALT,抗-HCV的对照组进行比较。结果:215例吸毒人员ALT异常,显著高于300例对照组,两组比较结果的差异有统计学意义(P<0.05)。215例吸毒人员HCV感染率为56%与对照组感染率1.3%之间的差异有统计学意义(P<0.05)。结论:吸毒者有明显的肝功能损害,吸毒者HCV感染情况比较严重,吸毒者ALT的异常与HCV感染有显著的关系。
Objective: To understand the relationship between abnormality of alanine aminotransferase (ALT) and hepatitis C virus (HCV) infection in intravenous drug users and provide a scientific basis for controlling the spread of hepatitis C. Methods: ALT was detected by continuous monitoring method. Meanwhile, the anti-HCV antibody was detected by enzyme-linked immunosorbent assay (ELISA) and compared with ALT and anti-HCV in the same period. Results: The abnormal ALT in 215 drug addicts was significantly higher than that in 300 controls. The difference between the two groups was statistically significant (P <0.05). 215 cases of drug addicts HCV infection rate of 56% and 1.3% of the control group, the difference was statistically significant (P <0.05). Conclusion: The drug users have obvious hepatic dysfunction, and the HCV infection among drug addicts is more serious. The abnormality of ALT among drug addicts has a significant relationship with HCV infection.