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目的探讨染色体异常与不良孕产史及不孕不育之间的内在关系。方法采用外周血淋巴细胞培养技术对342例有不良孕产史及不孕不育的患者进行常规G显带染色体核型分析。结果 342例患者中共检出异常核型31例,其中性染色体数目异常2例;平衡易位4例;性染色体结构异常2例;臂间倒位3例;染色体多态性18例。结论染色体异常是导致不良孕产史及不孕不育的重要原因之一,对有不良孕产史及不孕不育的患者进行细胞遗传学检查,以确定病因,从而选择适当的处理方法至关重要。
Objective To explore the relationship between chromosomal abnormalities and poor pregnancy history and infertility. Methods Peripheral blood lymphocyte culture technique was used to analyze the G-banding karyotypes of 342 patients with poor pregnancy history and infertility. Results There were 31 abnormal karyotypes detected in 342 patients, including 2 cases of abnormal chromosomal number, 4 cases of balanced translocation, 2 cases of sex chromosome abnormalities, 3 cases of in-arm inversion and 18 cases of chromosome polymorphism. Conclusion Chromosomal abnormalities are one of the important causes of adverse pregnancy history and infertility. Cytogenetic tests are performed on patients with bad pregnancy history and infertility to determine the cause of the disease and select the appropriate treatment Important.