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目的 探讨粒细胞集落刺激因子 (G CSF)在呼吸道感染个体中的变化。方法 采用双抗夹心酶联免疫法和免疫单扩法对 189例呼吸道感染急性期及 5 0例治疗后 5～ 7d患儿和 30例健康儿童进行血G CSF和C反应蛋白 (CRP)检测 ,同步外周血白细胞计数。结果 血G CSF阳性 10 5 /189例 (5 5 .5 6 % ) ,CRP阳性 6 8/189例 (35 .98% ) ,同一病人G CSF和CRP重叠阳性 45 /189例 (2 3.81% )。治疗后 5～ 7d复查 5 0例CRP全部转阴 ,G CSF 16 /5 0例 (32 % )持续阳性。结论 G CSF水平在急性感染时增高 ,对临床有一定指导意义。
Objective To investigate the changes of granulocyte colony stimulating factor (G CSF) in individuals with respiratory tract infection. Methods Serum G-CSF and C-reactive protein (CRP) levels were measured in 189 acute respiratory tract infections and 50 children in 5-7 days after treatment and 30 healthy children by double antibody sandwich enzyme-linked immunosorbent assay and immunoassay. Synchronous peripheral blood leukocyte count. Results There were 105/189 (55.6%) positive patients with G CSF positive and 68/189 (35.98%) positive patients with CRP, and 45 of 189 (23.8%) positive patients with G CSF and CRP overlap in the same patient . Fifty cases of CRP were negative after 5 ~ 7 days of treatment, and G CSF 16/50 cases (32%) persisted. Conclusion The level of G CSF is increased in acute infection, which is of clinical significance.