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为探讨硒化学诱癌剂所致胃粘膜上皮细胞损伤的防护作用，本文应用液闪法观察了不同浓度亚硒酸钠对ＭＮＮＧ诱导的胎胃粘膜上皮细胞非程序ＤＮＡ合成的影响。结果表明，加入亚硒酸钠１０－５Ｍ和１０Ｍ－６浓度组由ＭＮＮＧ诱导的非程序ＤＮＡ合成水平（８１．７±８．５，５１．０±６．０）显著低于对照组（１７９．０±１２．８）（Ｐ＜０．０５～０．０１），而１０－７Ｍ浓度组（１２５．０±１１．９）与对照组相比差别则无显著意义（Ｐ＞０．０５）。以上结果提示，一定浓度的亚硒酸钠对ＭＮＮＧ诱导的胃粘膜上皮细胞损伤有保护作用。
In order to explore the protective effect of selenium chemotherapeutic agent on gastric mucosal epithelial cell injury, the effects of different concentrations of sodium selenite on MNNG-induced non-procedural DNA synthesis of gastric mucosal epithelial cells were observed by liquid-flash method. The results showed that MNNG induced non-programmed DNA synthesis (81.7 ± 8.5, 51.0 ± 6.0) in 10-5M and 10M-6 concentrations of sodium selenite was significantly lower than that in control group (179 .0 ± 12.8) (P <0.05 ~ 0.01), but there was no significant difference between the 10-7M concentration group (125.0 ± 11.9) and the control group (P> 0.05 ). The above results suggest that certain concentrations of sodium selenite have a protective effect on MNNG-induced gastric mucosal epithelial cell injury.