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目的:探索台州三门地区妇女人乳头状瘤病毒(human papilloma virus,HPV)感染率、感染亚型分布及年龄特征。方法:利用PCR反向点杂交技术对2380例女性进行HPV检测,并进行分型。结果:2380例样本中检出阳性病例674例,总感染率为28.3%。高危型中感染率最高的是HPV16型和HPV52型,阳性率分别为6.01%和4.58%。低危型中感染率最高的是HPV43型,阳性率为2.85%,其次分别是HPV6型和HPV11型,阳性率分别是1.60%和1.34%。HPV感染高峰在21岁~30岁,41岁以后逐渐下降,51岁以后明显下降,各年龄段HPV感染检出率差异有统计学意义(P<0.01)。结论:HPV分型检测对女性宫颈病变临床诊断及大规模筛查有重要价值。
Objective: To explore the infection rate, distribution and age characteristics of human papilloma virus (HPV) in Sanmen area, Taizhou. Methods: 2380 women were tested for HPV by reverse dot blot hybridization and genotyped. Results: A total of 674 positive cases were detected in 2380 samples, the total infection rate was 28.3%. High-risk type infection is the highest HPV16 and HPV52 type, the positive rates were 6.01% and 4.58%. The highest infection rate in low-risk type was HPV43, the positive rate was 2.85%, followed by HPV6 and HPV11 respectively, the positive rates were 1.60% and 1.34% respectively. The peak of HPV infection was between 21 and 30 years old, gradually decreased after 41 years of age, and obviously decreased after 51 years of age. There was significant difference in HPV infection among all age groups (P <0.01). Conclusion: HPV typing test has important value in clinical diagnosis and large-scale screening of female cervical lesions.