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目的 观察伴缺血性心脑血管病变的高血压病人血小板活化的改变 ,探讨其在血栓性疾病发生中的价值。方法 用流式细胞术测定 4 0例伴缺血性心脑血管病变高血压病人及 4 6例无缺血性血管病变高血压病人血小板活化指标CD6 2p、CD6 3的改变 ,两组间进行比较并分别与 30例健康对照组进行比较。同时测定血浆纤维蛋白原浓度。结果 CD6 2 p、CD6 3:两组高血压病人均显著高于正常对照组 (P <0 0 5～ 0 0 1) ,伴血管病变高血压组显著高于无血管病变高血压组 (P <0 0 1)。血浆纤维蛋白原 :伴血管病变高血压组显著高于无血管病变高血压组及对照组 (P <0 0 1) ;无血管病变高血压组与对照组比差异无显著性。结论 伴缺血性心脑血管病变高血压病人的血小板活化程度增高 ,在高血压合并血栓性疾病的检测中 ,血小板活化指标比血浆纤维蛋白原更敏感
Objective To observe the changes of platelet activation in hypertensive patients with ischemic cardiovascular and cerebrovascular diseases and explore its value in the development of thrombotic diseases. Methods Flow cytometry was used to determine the changes of platelet activation markers CD6 2p and CD6 3 in 40 patients with hypertension with ischemic cardiovascular and cerebrovascular diseases and in 46 patients with non-ischemic vascular disease. Comparisons were made between the two groups And compared with 30 healthy controls respectively. Simultaneous determination of plasma fibrinogen concentration. Results CD6 2 p and CD6 3 in both groups were significantly higher than those in the normal control group (P <0.05-0.01), those with vascular lesion in the hypertension group were significantly higher than those in the non-vascular group (P < 0 0 1). Plasma fibrinogen: hypertension with vascular disease group was significantly higher than those without vascular disease and control group (P <0.01); no vascular disease group compared with the control group no significant difference. Conclusion Platelet activation is elevated in hypertensive patients with ischemic cardiovascular and cerebrovascular diseases. In the detection of hypertension complicated with thrombotic diseases, the platelet activation index is more sensitive than plasma fibrinogen