论文部分内容阅读
鞭毛蛋白是细菌鞭毛的主要成分,是脓毒症发病过程中强有力的前炎性致炎因子,能和TRL5结合并使之活化,激活NF-κB等转录因子,引起多种趋化因子和黏附分子分泌。在健康的志愿者中,血浆中鞭毛蛋白的浓度低于ELISA<0.1μg/mL的检测水平,而在脓毒症的患者中,血浆中鞭毛蛋白的浓度为(7.06±0.14)μg/mL,并且外周血鞭毛蛋白的水平和脓毒症持续的时间、肺损伤的程度、肺泡肺小动脉氧张力差值呈明显的正相关,和白细胞的减少程度也有相关的趋势。
Flagellin, a major component of bacterial flagella, is a potent pro-inflammatory proinflammatory factor in the pathogenesis of sepsis. It binds to TRL5 and activates it, activates transcription factors such as NF-κB, and causes a variety of chemokines and Adhesion molecule secretion. In healthy volunteers, plasma concentrations of flagellin are below the detection level of ELISA <0.1 μg / mL, whereas in sepsis patients the plasma concentration of flagellin is (7.06 ± 0.14) μg / mL, And the level of peripheral blood flagellin and the duration of sepsis, the degree of lung injury, alveolar pulmonary arterial oxygen tension difference was significantly positively correlated, and the degree of leukocyte reduction is also related trend.