定义再生障碍性贫血(简称再障)是一组出化学、物理、生物因素及尚未知的原因引起骨髓干细胞及造血微环境损伤,以致红髓被脂肪髓代替,血中及血细胞减少的疾病。病因与发病机制再障分为体质性和获得性两大类,所谓体质性是指有家族倾向或伴有先天异常的先天性再障,本章主要讨论获得性再障,获得性再障又分为两类,一是原因不明,二是有因可查,所谓原因不明的获得性再障实际是引起该类再障的原因尚未被人们发 Definition Aplastic anemia (referred to as aplastic anemia) is a group of chemical, physical, biological factors and unknown causes of bone marrow stem cells and hematopoietic microenvironment damage, resulting in the replacement of red pulp by the fatty marrow, blood and cytopenia of the disease. Etiology and pathogenesis Aplastic anemia is divided into two major categories of physical and acquired, the so-called constitutional refers to a family tendency or congenital anomalies associated with congenital aplastic anemia, this chapter focuses on acquired aplastic anemia, acquired aplastic anemia For two categories, one is the reason is unknown, the second is due to be found, the so-called unexplained acquired aplastic anemia is actually caused by such a cause of aplastic anemia has not been made