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利用水相合成法制备了三巯基丙酸包裹的Mn掺杂ZnS量子点(MPA-Mn/ZnSQDs),基于该量子点的室温磷光性质,构建了一种定量检测盐酸洛美沙星(LFLX)的新方法。在最优实验条件下(pH7.4,反应时间10min),LFLX浓度在0.002~1.4μg/mL范围内与MPA-Mn/ZnSQDs的磷光猝灭强度呈良好的线性关系(r=0.993),方法检出限为0.7×10-3μg/mL。该方法相对无共存物质的干扰,并适用于LFLX眼药水及人体尿样中LFLX的快速检测。
The Mn-doped ZnS quantum dots (MPA-Mn / ZnSQDs) coated with trimercaptopropionic acid were prepared by aqueous phase synthesis method. Based on the room-temperature phosphorescence properties of the quantum dots, a method was developed for the quantitative determination of Limefloxacin Hydrochloride (LFLX) new method. Under the optimal experimental conditions (pH7.4, reaction time 10min), the concentration of LFLX showed a good linear relationship (r = 0.993) with the phosphorescence quenching intensity of MPA-Mn / ZnSQDs in the range of 0.002-1.4μg / The detection limit was 0.7 × 10-3 μg / mL. This method is relatively non-coexistent substance interference and is suitable for the rapid detection of LFLX in LFLX eye drops and human urine samples.