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以红霉素为代表的大环内酯类抗生素具有安全性好、半衰期长、服用方便、可用于孕妇及儿童等特性,尤其是随着其家族新成员的不断涌现,其用途早已从青霉素过敏时的替代治疗拓展到对许多新的感染性和非感染性疾病的治疗。本文就其在疟疾、弓形虫脑炎、小螺菌鼠咬热、人埃立克体病、分枝杆菌病、Q热肝炎、散在复发性斑疹伤寒、Whipple病、弯曲菌病、汉赛巴尔通体病、卡氏肺孢子虫病、霍乱弧菌O139感染、中毒性休克综合征,以及细菌生物膜病等感染性疾病中应用的最新进展作了综述。
Macrolide antibiotics, represented by erythromycin, have the characteristics of good safety, long half-life, convenient taking and can be used for pregnant women and children. Especially with the continuous emergence of new members of their family, their use has long been allergic to penicillin At the time of alternative treatment extended to the treatment of many new infectious and non-infectious diseases. In this paper, its malaria, toxoplasma encephalitis, spirochete echinococcosis, ehrlichiosis, mycobacterial disease, Q hot hepatitis, scattered recurrent typhus, Whipple disease, Campylobacter, Han Barton’s disease, Pneumocystis carinii disease, Vibrio cholerae O139 infection, toxic shock syndrome, and bacterial biofilm disease and other infectious diseases are reviewed.