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以1,3-金刚烷二甲酸为起始原料,合成了3种以金刚烷为联接链的具有不同疏水链长的Gemini表面活性剂(n P-Ad-Pn,n=12,14,16)。用FTIR、1HNMR、ESI-MS对目标化合物的结构进行了表征。采用表面张力法、电导率法和稳态荧光光谱法测定了金刚烷Gemini表面活性剂的表面活性、胶束化热力学参数和胶束微极性。结果显示:白金环法测得n P-Ad-Pn在25℃下的临界胶束浓度分别为6.0×10-4、1.0×10-4和2.5×10-5mol/L,ΔG0m和ΔH0m均为负值说明表面活性剂胶束形成是一个自发且放热的过程。化合物对金黄色葡萄球菌、枯草杆菌、大肠杆菌、绿脓杆菌、副溶血性弧菌抑菌活性的测定结果表明,12P-Ad-P12对5种菌株的MIC值在0.2~4.2mg/L,显示出很强的抑菌活性。
Using 1,3-adamantane dicarboxylic acid as a starting material, three Gemini surfactants with different hydrophobic chain lengths (nP-Ad-Pn, n = 12, 14, ). The structure of the target compound was characterized by FTIR, 1HNMR and ESI-MS. The surface activity, micellar thermodynamic parameters and micellar micropolarity of the adamantane Gemini surfactant were measured by surface tension method, conductivity method and steady-state fluorescence spectroscopy. The results showed that the critical micelle concentrations of nP-Ad-Pn at 25 ℃ were 6.0 × 10-4, 1.0 × 10-4 and 2.5 × 10-5mol / L, respectively, and both ΔG0m and ΔH0m were Negative values indicate that surfactant micelle formation is a spontaneous and exothermic process. The results of antibacterial activity of the compounds against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Vibrio parahaemolyticus showed that MIC values of 12P-Ad-P12 against five strains ranged from 0.2 to 4.2 mg / L, Show a strong antibacterial activity.