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目的探讨国产甲型H1N1流行性感冒裂解疫苗(简称甲流疫苗)接种后的免疫持久性。方法采用多阶段随机抽样方法,抽取3～5岁、6～10岁、11～15岁、16～20岁、21～40岁、41～60岁和>60岁7个年龄组共350人作为监测对象。使用微量血凝抑制(haemagglutination inhibition,HI)实验测定监测对象接种甲流疫苗前、接种后28 d和6个月甲流抗体水平。结果接种甲流疫苗后6个月的HI抗体平均滴度、阳转率和保护率均低于接种后28 d;3～5岁和>60岁两个年龄组接种后28 d抗体几何平均滴度高于接种后6个月(均有P<0.05);3～5岁、6～10岁和11～15岁3个年龄组接种后28 d和6个月HI抗体阳转率差异均有统计学意义(均有P<0.05)。结论国产甲流疫苗能产生较好的免疫应答,并有一定的免疫持久性。
Objective To investigate the immune persistence of domestic influenza A (H1N1) influenza vaccine (abbreviated as Influenza A). Methods A total of 350 people in 7 age groups from 3 to 5 years old, 6 to 10 years old, 11 to 15 years old, 16 to 20 years old, 21 to 40 years old, 41 to 60 years old and> 60 years old were selected as the method of multi-stage random sampling Monitoring object. The level of antibody against influenza A was measured at 28 d and 6 months after vaccination with the haemagglutination inhibition (HI) test, before and after vaccination. Results The average titer, positive conversion rate and protection rate of HI antibody at 6 months after inoculation were lower than those at 28 days after inoculation. Geometrical average drops of antibody at 28 days after inoculation (P <0.05). The positive rate of HI antibody in 28 days and 6 months after inoculation in 3 ~ 5, 6 ~ 10 and 11 ~ 15 age groups Statistical significance (all P <0.05). Conclusion Domestic flu vaccine can produce a better immune response, and have a certain immune persistence.