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目的探讨高同型半胱氨酸血症(Hhcy)在脑梗死发病机制中的作用。方法选取急性脑梗死患者,根据血浆总同型半胱氨酸(tHcy)水平,将其分为 Hhcy 组和非 Hhcy(Nhhcy)组,除外脑血管疾病和肝肾甲状腺疾病患者40例作为对照。分别测血浆 tHcy、血清丙二醛(MDA)、白细胞介素-8(IL-8)水平,并研究其相关性。结果病例组 tHcy(μmol/L,下同)、MDA(nmol/L,下同)、IL-8(ng/ml,下同)水平分别为19.97、4.4l±0.84、0.23±0.08,显著高于对照组的9.83、3.24±0.64、0.12±0.08,t 值分别为8.139,8.021,7.767(均 P<0.01);病例组中 Hhcy 患者的 tHey、MDA、IL-8水平分别为24.40、4.70±0.76、0.25±0.07,显著高于 Nhhcy 患者的10.33、3.76±0.61、0.16±0.06,￡值分别为13.213,6.543,6.520(P<0.01)。tHcy 水平与 MDA、IL-8水平具有相关性(P<0.01)。结论 Hhcy 在脑梗死发病机制中的作用可能与其参与氧化应激反应和炎症损伤过程有关。
Objective To investigate the role of homocysteine (Hcy) in the pathogenesis of cerebral infarction. Methods A total of 40 patients with acute cerebral infarction were divided into Hhcy group and non-Hhcy group according to the level of plasma total homocysteine (tHcy), except for 40 patients with cerebrovascular disease and hepatorenal and thyroid diseases. Plasma tHcy, serum malondialdehyde (MDA), interleukin-8 (IL-8) levels were measured and their correlations were studied. Results The levels of tHcy (μmol / L, the same below), MDA (nmol / L, the same below) and IL-8 (ng / ml, the same below) were 19.97, 4.41 ± 0.84 and 0.23 ± 0.08 The values of tHey, MDA and IL-8 in the Hhcy patients were 9.83, 3.24 ± 0.64, 0.12 ± 0.08 and 8.139, 8.021, 7.767 respectively (all P <0.01) 0.76 and 0.25 ± 0.07, respectively, which were significantly higher than those of Nhhcy patients (10.33, 3.76 ± 0.61 and 0.16 ± 0.06), respectively, with the values of 13.213, 6.543 and 6.520 respectively (P <0.01). The level of tHcy was correlated with the levels of MDA and IL-8 (P <0.01). Conclusions The role of Hcy in the pathogenesis of cerebral infarction may be related to its involvement in oxidative stress and inflammatory injury.