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目的:探讨沙美特罗替卡松吸入联合孟鲁斯特纳(顺尔宁)口服治疗儿童哮喘的治疗效果。方法:将85例支气管哮喘患儿随机分为观察组和对照组,在常规治疗的基础上,观察组患者应用沙美特罗替卡松粉吸入剂及顺尔宁,对照组患者应用沙美特罗替卡松粉吸入剂,治疗周期均为3个月。比较两组患儿治疗前后哮喘症状评分的变化及治疗前后肺功能的变化。结果:治疗后,两组患者日间及夜间哮喘症状评分均显著改善,且观察组患者改善更加明显(P<0.05)。治疗后,观察组患者MVV、VC、FVC及FEV1改善均显著优于对照组(P<0.05)。治疗后2～7天,观察组患者PEF变异率均显著优于对照组(P<0.05)。结论:沙美特罗替卡松吸入联合顺尔宁口服治疗儿童哮喘能够明显改善患儿症状及肺功能,具有很高的应用价值。
Objective: To investigate the therapeutic effect of salmeterol and terbutaline on oral treatment of childhood asthma with Montelukastin (Salbutamol). Methods: Eighty-five children with bronchial asthma were randomly divided into observation group and control group. On the basis of conventional treatment, the patients in observation group were treated with salmeterol and rosin, Ticamycin powder inhaler, treatment cycles are 3 months. The changes of asthma symptom score before and after treatment and the changes of pulmonary function before and after treatment were compared between the two groups. Results: After treatment, the scores of asthma symptoms in both groups were significantly improved during the day and night, and the improvement in the observation group was more obvious (P <0.05). After treatment, the improvement of MVV, VC, FVC and FEV1 in the observation group was significantly better than that in the control group (P <0.05). 2 to 7 days after treatment, the observation group patients PEF mutation rate was significantly better than the control group (P <0.05). Conclusion: The combination of salmeterol and fluticasone in combination with salbutamol oral treatment of children with asthma can significantly improve children’s symptoms and lung function, which is of high value.