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骨髓间质干细胞（ MSCs）是由中胚层发育而来的一类成体干细胞，存在于全身结缔组织和器官间质中，属于骨髓非造血干细胞，具有干细胞的一般特性，即自我更新以及多向分化能力。 MSCs能够促进结直肠肿瘤的生长。在肿瘤条件下，骨髓中的MSCs随血运迁至肿瘤微环境，参与肿瘤的构建过程。 MSCs促进肿瘤侵袭的机制是复杂的，包括MSCs转化为肿瘤相关纤维母细胞（TAF）参与肿瘤间质的形成以及MSCs对微环境的调节作用。 MSCs在结直肠癌靶向治疗策略中的应用前景是广阔的，通过不断地研究，将为MSCs安全地在临床中应用提供新的理论依据。“,”Mesenchymal stem cells(MSCs) is a type of adult stem cells,which are developed from meso-derm.It was found in the interstitial connective tissue and organs,and belongs to the bone marrow hematopoi-etic stem cells.It has the general characteristic of stem cells,namely the ability of self-renewal and multi-di-rectional differentiation .MSCs could promote the growth of colorectal cancer .Under the condition of the tumor microenviroment,the MSCs move along with the blood stream to the tumor microenvironment,participate in the process of the construction of the tumor .The mechanism that MSCs promoting tumor invasion is complex , which includes MSCs into TAFs (Tumor associated fibroblast,TAF) in the regulation of tumor microenviro-ment.The prospect of MSCs in colorectal cancer targeted therapy strategy is bright ,these research will provide new theoretical basis for its safety applications .