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前言 Wattenberg等报道抗氧化剂3-叔丁基-4-羟基苯甲醚(BHA)可抑制各种组织的化学致癌过程。Benson等以及Lam等进一步证明,在BHA抑制化学致癌机理中,谷胱甘肽-S-转移酶(G-SH-Stransferase)和环氧化物水化酶(epoxidehydrase)起重要作用。本文作者曾在观察药物代谢酶,特别是解毒系统酶在肝脏化学致癌过程中的作用时,发现在肝脏癌前细胞(增生性结节)的形成过程中,尿苷二磷酸葡萄糖醛酸基转移酶(以下简称“UDP-
Foreword Wattenberg et al. reported that the antioxidant 3-tert-butyl-4-hydroxyanisole (BHA) inhibits the chemical carcinogenesis of various tissues. Benson et al. and Lam et al. further demonstrated that glutathione-S-transferase (G-SH-Stransferase) and epoxide hydratase play an important role in the inhibition of chemical carcinogenesis by BHA. The author of this article observed the effects of drug-metabolizing enzymes, particularly detoxification system enzymes, in the process of liver chemical carcinogenesis and found that during the formation of hepatic precancerous cells (proliferative nodules), uridine diphosphate glucuronosyltransferase Enzyme (hereinafter referred to as “UDP-”