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目的:探讨奥卡西平治疗小儿难治性癫痫病的临床效果及安全性。方法:选取我院2010年5月—2012年10月收治小儿难治性癫痫病患儿148例,采用随机数字表法分为对照组和观察组,对照组患儿给予苯巴比妥钠片口服治疗,观察组患儿给予奥卡西平口服治疗,比较两组患儿临床改善总有效率、发作次数、认知功能、生活质量、不良反应发生情况。结果:观察组患儿临床改善总有效率(85.14%)明显高于对照组(70.27%)(P<0.05);发作次数(3.65±0.85)明显低于对照组,生活质量(72.32±7.56)明显高于对照组(P<0.05);观察组患儿恶心呕吐、头晕头痛、皮疹及嗜睡等不良反应发生率均明显低于对照组,组间比较差异显著(P<0.05)。结论:奥卡西平治疗小儿难治性癫痫病可有效改善临床症状,降低不良反应发生风险,具有临床使用价值。
Objective: To investigate the clinical efficacy and safety of oxcarbazepine in the treatment of refractory epilepsy in children. Methods: A total of 148 children with refractory epilepsy in our hospital from May 2010 to October 2012 were selected and randomly divided into control group and observation group. The control group received phenobarbital sodium tablets Oral treatment, observation group of children given oxcarbazepine oral treatment, the clinical improvement of the two groups were compared the total effective rate, the number of attacks, cognitive function, quality of life, adverse reactions. Results: The total effective rate (85.14%) in observation group was significantly higher than that in control group (70.27%) (P <0.05); the number of attacks was significantly lower than that in control group (72.52 ± 7.56) (P <0.05). The incidence of nausea and vomiting, dizziness, headache, rash and drowsiness in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: Oxcarbazepine treatment of children with refractory epilepsy can effectively improve the clinical symptoms and reduce the risk of adverse reactions, with clinical value.