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恶性胶质瘤年发病率约为5/100,000。美国每年有超过14,000例的新发恶性脑胶质瘤患者。治疗主要以手术治疗为主,手术肿瘤的切除程度影响患者的预后。外科手术治疗脑肿瘤需要精确定位脑肿瘤组织在正常脑组织中的位置以便能够获得精确的组织活检和肿瘤的完全切除。量子点是稳定存在的,产生荧光的可视化半导体纳米晶体。静脉注射量子点伴随着网状内皮系统和巨噬细胞的隔离。巨噬细胞可渗入到肿瘤组织并且能够吞噬通过静脉注射的光量子来产生可视化的肿瘤标记。通过巨噬细胞介导,将光量子运输至肿瘤组织展现了一种新兴技术来标记术前肿瘤组织。由于肿瘤组织中的光量子可以被光学成像和光谱学工具来探测,因此在脑肿瘤组织活检和切除中可以为外科医生提供可视化得实时反馈。
The annual incidence of glioblastoma is about 5 / 100,000. In the United States, there are more than 14,000 new cases of malignant gliomas each year. The main treatment of surgical treatment, the degree of surgical resection of the tumor affected the prognosis of patients. Surgical treatment of brain tumors requires precise positioning of brain tumor tissue in normal brain tissue so that accurate biopsy and complete resection of the tumor can be achieved. Quantum dots are a stable, fluorescent, visualized semiconductor nanocrystal. Intravenous injection of quantum dots is accompanied by the isolation of the reticuloendothelial system and macrophages. Macrophages can penetrate into tumor tissue and are capable of phagocytosing light quanta through intravenous injection to create visualized tumor markers. By macrophage-mediated delivery of light to tumor tissue, a new technique is emerging to mark preoperative tumor tissue. Since light quanta in tumor tissue can be detected by optical imaging and spectroscopy tools, it is possible to provide surgeons with visual real-time feedback in brain tumor biopsies and resections.