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目的对妇科恶性肿瘤介入治疗后的副反应及并发症进行分析,并就其原因、处理措施、如何避免进行探讨。方法对经病理证实的82例妇科恶性肿瘤患者做介入治疗120次,采用Seldinger技术,右侧股动脉插管,两侧髂内动脉或子宫动脉灌注化疗药物或子宫动脉栓塞。结果介入治疗后的副反应包括不同程度的化疗反应和栓塞综合征,本组患者中出现此类副反应的有72例(90%),表现为发热、恶心、呕吐及白细胞减少等,另有8例(10%)表现为尿急、尿频、尿痛等膀胱刺激症状,3例(3.6%)患者并发严重的会阴部及臀部皮肤、皮下组织缺血坏死。结论妇科恶性肿瘤介入治疗后的副反应及并发症发生的原因有短时间灌注化疗药物用量过大、过浓,靶动脉异常分支,插管过深以及栓塞颗粒太小致误栓等。
Objective To analyze the side effects and complications after interventional treatment of gynecologic malignancies and to avoid the discussion on its causes and treatment measures. Methods A total of 82 cases of gynecological malignant tumors confirmed by pathology were treated 120 times with Seldinger technique, right femoral artery cannulation, bilateral internal iliac artery or uterine artery infusion chemotherapy drugs or uterine artery embolization. The results of interventional treatment of side effects include varying degrees of chemotherapy and embolism syndrome, this group of patients appeared in 72 cases (90%) of these side effects, manifested as fever, nausea, vomiting and leukopenia, and the other Eight cases (10%) showed urinary urgency, frequent urination, dysuria and other irritation of the bladder. Three patients (3.6%) had severe perineal and posterior skin and subcutaneous tissue necrosis. Conclusions The side effects and complications of interventional gynecological malignancies may be caused by overdosage of chemotherapy drugs, excessive branching of the target artery, excessive intubation, and embolization of too small embolic particles.