论文部分内容阅读
对３例原发性失神性癫痫患儿进行２４ｈ痫样放电的定量分析。结果表明，非快速眼动（ＮＲＥＭ）睡眠期痫样放电频度较醒觉期显著增多，而每次放电持续时间显著缩短，放电失去全导同步３Ｈｚ节律性爆发的特征，表现为不规则棘慢波、多棘慢波以杂乱无序的形式出现，以前头部为主，多种放电现象可出现于同一患儿的同一睡眠相。提示儿童原发性失神性癫痫可能系皮层多位点起源，并受到丘脑等皮层下结构的调控。其脑电的去同步化可能对皮层的放电有抑制作用。ＮＲＥＭ睡眠期可能在皮层水平触发多处放电。临床上，２４ｈＥＥＧ监测可定量检出临床发作及放电频率，正确判断睡眠中的异常放电，确定抗癫痫药物的治疗效果。
Quantitative analysis of 24 h epileptiform discharges in 3 children with primary dementia epilepsy. The results showed that the discharge frequency of epileptiform discharge in non-REME increased significantly more than that of awake phase, but the duration of each discharge was significantly shortened, and the discharge lost the feature of all-conduction 3Hz rhythmic burst characterized by irregular spines Slow waves, spikes and waves slowly messy disorder appeared in the form of the former head-based, a variety of discharge phenomena can occur in the same child with the same sleep phase. It is suggested that primary deafness epilepsy in children may be the origin of multiple cortical sites and is regulated by the subcortical structure of the thalamus. The EEG desynchronization may have an inhibitory effect on the cortical discharge. NREM sleep may trigger multiple discharges at the cortical level. Clinically, 24hEEG monitoring quantitative detection of clinical seizures and discharge frequency, correctly determine the abnormal discharge during sleep to determine the antiepileptic drug treatment.